Status:
NOT_YET_RECRUITING
Effect of EIT-guided PEEP On Clinical Outcomes in ARDS Patients: a Randomized Controlled Trial
Lead Sponsor:
Southeast University, China
Conditions:
ARDS (Acute Respiratory Distress Syndrome)
Eligibility:
All Genders
19-85 years
Phase:
NA
Brief Summary
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lu...
Eligibility Criteria
Inclusion
- Age≥18 years
- Moderate-to-severe ARDS, defined by the ARDS Definition Task Force in the Berlin definition (partial pressure of arterial oxygen \[PaO2\]:FiO2 ratio ≤200 mmHg with a PEEP ≥5 cmH2O)
- RI ratio \> 0.5 measured for clinical reasons in the previous 24 hours
- Diagnosis of ARDS less than 72 hours
Exclusion
- Expected to be mechanically ventilated for less than 48 hours
- Severe chronic respiratory diseases requiring long-term home oxygen therapy or noninvasive MV
- Undrained pneumothorax or subcutaneous emphysema
- Undergoing extracorporeal membrane oxygenation (ECMO) before enrollment
- Contraindication to the use of EIT (pacemaker, automatic implantable cardioverter defibrillator, and implantable pumps)
- Severe neuromuscular disease
- Hemodynamic instability
- Contraindications to hypercapnia, such as intracranial hypertension or acute coronary syndrome
- Severe other organs dysfunction with a low expected survival (7 days) or palliative care
- Solid organ or hematologic tumors with the expected survival time less than 30 days
- Participating in other clinical trials within 30 days
- Pregnancy
- Refusal to sign the informed consent
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 20 2026
Estimated Enrollment :
264 Patients enrolled
Trial Details
Trial ID
NCT06990477
Start Date
December 1 2025
End Date
February 20 2026
Last Update
October 2 2025
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