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Status:

RECRUITING

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Lead Sponsor:

Pfizer

Conditions:

Heart Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Detailed Description

All participants in this study will take either the study medicine (PF-07328948) tablets, or placebo tablets, once daily, by mouth, every day for 36 weeks. The study determines if the study medicine (...

Eligibility Criteria

Inclusion

  • This study is seeking participants who are:
  • Key Inclusion Criteria include:
  • aged 18 years or older.
  • \- clinically confirmed to have a diagnosis of heart failure for at least 3 months
  • New York Heart Association Class II-IV symptoms
  • left ventricular ejection fraction greater than 40%
  • Body mass index of 27 kg/m2 or higher
  • Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
  • Six-minute walking distance greater than 75 meters
  • Key Exclusion Criteria include:
  • Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
  • Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
  • History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
  • Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor

Exclusion

    Key Trial Info

    Start Date :

    June 19 2025

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    December 14 2027

    Estimated Enrollment :

    620 Patients enrolled

    Trial Details

    Trial ID

    NCT06991257

    Start Date

    June 19 2025

    End Date

    December 14 2027

    Last Update

    August 14 2025

    Active Locations (24)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 6 (24 locations)

    1

    National Heart Institute

    Beverly Hills, California, United States, 90211

    2

    Orange County Research Center

    Lake Forest, California, United States, 92630

    3

    FWD Clinical Research

    Boca Raton, Florida, United States, 33486

    4

    Amavita Research Services

    North Miami Beach, Florida, United States, 33169