Status:
COMPLETED
Comparison Between the Progostic Value of the Procalcitonin and the Platelet/Total Leukocytic Count Ratio in Sepsis
Lead Sponsor:
Ain Shams University
Conditions:
All Conditions Causing Sepsis
Pneumonia - Bacterial
Eligibility:
All Genders
21+ years
Brief Summary
What is already known on this subject? AND What does this study add? Sepsis is a complicated condition caused by a malfunction of the host's immune response to infection, which results in an uncontrol...
Detailed Description
What is already known on this subject? AND What does this study add? Sepsis is a complicated condition caused by a malfunction of the host's immune response to infection, which results in an uncontrol...
Eligibility Criteria
Inclusion
- Age more than 21 years.
- Patients presented with sepsis defined as a suspected source of infection plus ≥2 of the following:
- Fever of \>38º or hypothermia \<36º
- Heart rate of \>90 beats/min
- Respiratory rate of \>20 breaths per minute or PaCO2 \<32 mmHg
- White blood cells \>12 x 109/cmm or \<4 x 109/cmm, or \>10% immature forms.
- Patients presented with severe sepsis defined as sepsis associated with secondary organ dysfunction.
Exclusion
- Age less than 21 years.
- Patients with acute cerebro-vascular event.
- Patients on chemotherapy.
- Patients with malignant hematological disease.
- Patients with immunosuppression.
- Patients with active hemorrhage.
- Patients who had used anti-PLT drugs such as clopidogrel prior to admission.
- Patients with life threating medical comorbidities (e.g.intractable heart failure, hepatic encephalopathy).
- Patients diagnosed with heparin induced thrombocytopenia (HIT).
- Patients on medications that help reducing platelet count such as linezolid.
Key Trial Info
Start Date :
September 27 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 10 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06991686
Start Date
September 27 2024
End Date
March 10 2025
Last Update
June 18 2025
Active Locations (1)
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1
Faculty of Meidcine Ain Shams University
Cairo, Egypt