Status:
COMPLETED
Efficacy of HFNC Combined With Sequential NIV in Patients With COPD Complicated With Type II Respiratory Failure
Lead Sponsor:
Beijing YouAn Hospital
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Nasal High Flow Oxygen Therapy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to investigate the efficacy of high-flow nasal cannula oxygen therapy (HFNC) combined with sequential non-invasive ventilation (NIV) in patients with chronic obstruc...
Eligibility Criteria
Inclusion
- All subjects included in the study met the diagnostic criteria for AECOPD in the Global Initiative for Chronic Obstructive Pulmonary Disease (2014 Update);
- Age \> 18 years old;
- All patients met the diagnostic criteria for type II respiratory failure in the eighth edition of ' Internal Medicine ', that was, arterial blood PaO2 \< 50mmHg;
- The patient was conscious, without myocardial infarction, acute stroke, severe liver and kidney dysfunction, severe coagulation dysfunction and other diseases;
- The patient did not have life-threatening hypoxemia and severe hemodynamic instability, and did not need tracheal intubation or tracheotomy;
- Patients can cooperate with pulmonary function tests.
Exclusion
- Patients with pneumothorax, mediastinal emphysema or severe thoracic deformity;
- Patients with bronchial asthma, interstitial pneumonia and other diseases;
- Patients with coma and disturbance of consciousness;
- The upper respiratory tract or facial injury and facial deformity, can not wear a good nose (face) mask;
- Patients with septic shock or severe heart, kidney, liver and other diseases;
- Sputum and sticky, unable to expectoration or prone to aspiration caused by airway obstruction.
- Automatic discharge or transfer, or due to non-respiratory serious diseases (including non-invasive ventilator complications, non-invasive ventilation treatment ineffective need to be changed to invasive ventilation), termination of the study patients.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06992479
Start Date
January 1 2021
End Date
January 31 2024
Last Update
May 28 2025
Active Locations (1)
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1
Beijing You'an Hospital, Capital Medical University
Beijing, China