Status:
RECRUITING
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
Lead Sponsor:
Xiangya Hospital of Central South University
Conditions:
Cardiac Arrest
Post-cardiac Arrest Care
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood so...
Eligibility Criteria
Inclusion
- Age ≥ 18 years and \< 80 years
- Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes;
- Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points;
- Family members or legal representatives signed informed consent.
Exclusion
- Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes;
- Time from cardiac arrest to ROSC \> 60 minutes;
- Patients who woke up immediately after ROSC by CPR;
- End-stage diseases;
- Cardiac arrest considered to be caused by neurological diseases;
- The patient was in a vegetative state before cardiac arrest;
- The interval from the onset of cardiac arrest to enrollment is \>72 hours .
Key Trial Info
Start Date :
October 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
1008 Patients enrolled
Trial Details
Trial ID
NCT06992843
Start Date
October 22 2025
End Date
August 1 2027
Last Update
November 18 2025
Active Locations (1)
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1
Xiangya hospital，Central South University
Changsha, Hunan, China, 410000