Status:
NOT_YET_RECRUITING
Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Stichting ParkinsonNL
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Parkinson Disease
Prodromal Stage
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily ...
Detailed Description
Rationale: Parkinson's Disease (PD) is the fastest growing neurodegenerative disease. Exercise beneficially effects motor symptoms and neuroplasticity in people with PD. However, disease-slowing inter...
Eligibility Criteria
Inclusion
- Inclusion criteria
- previously identified LRRK2 G2019S or GBA N370S variant based on genotyping
- aged 50 years or older
- able to understand the English language
- being able to walk independently inside the home without the use of a walking aid
- in possession of a suitable smartphone (screen size minimum 4.6 inch), (Android version 9 or iOS version 15 or newer)
- Not in a high physical activity range during the 4-week eligibility and baseline period
- Exclusion criteria
- clinically diagnosed or self-reported diagnosis neurodegenerative disease
- self-reported falls of three or more per year
- dexterity problems or cognitive impairments hampering smartphone use
- if they are not aware of and do not wish to be informed about an increased risk of developing diseases associated with the LRRK2 or GBA1 risk variant
- if individual is not community-dwelling
- in possession of one of the following devices: Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite (Fitbit is incompatible)
Exclusion
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT06993142
Start Date
July 1 2025
End Date
June 30 2029
Last Update
June 3 2025
Active Locations (2)
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1
University of Rochester Center for Health and Technology (CHeT)
Rochester, New York, United States, 14642
2
Radboud University Medical Center
Nijmegen, Gelderland, Netherlands, 6525 GA