Status:
RECRUITING
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Glaucoma
Eligibility:
All Genders
18+ years
Brief Summary
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness betw...
Detailed Description
This study explores the biomechanical properties of the cornea in patients with glaucoma using a novel, non-contact imaging technique called Brillouin microscopy. The technology allows in vivo assessm...
Eligibility Criteria
Inclusion
- \- Age 18 years or older
- Diagnosis of primary open angle glaucoma (POAG) or no history of glaucoma (for controls)
- Open angle on gonioscopy (Shaffer grade 3 or 4)
- Best-corrected visual acuity of 20/25 or better
- Refractive error between +3.00 and -5.00 diopters
- No prior use of topical glaucoma medications
- Diagnosis of:
- High Tension Glaucoma (IOP ≥ 22 mmHg on 3 visits)
- Normal Tension Glaucoma (IOP ≤ 21 mmHg on 3 visits)
- OR age-matched control with normal optic nerve and visual fields
Exclusion
- Corneal abnormalities or conditions interfering with Brillouin or applanation tonometry
- Retinal diseases affecting RNFL (e.g., macular traction)
- History of ocular surgery or laser
- Diagnosis of diabetes
- History of uveitis
- History of prolonged steroid use
- Neurodegenerative or systemic diseases (e.g., multiple sclerosis, Alzheimer's, Parkinson's, schizophrenia)
- Unreliable visual fields
- Contraindications to beta blockers (e.g., bradycardia, severe pulmonary disease)
- Moderate to severe glaucoma (per Hodapp-Anderson-Parrish criteria)
- History of contact lens use
- Low blood pressure
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06993597
Start Date
September 1 2025
End Date
June 1 2026
Last Update
September 9 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Maryland School of Medicine
Baltimore, Maryland, United States, 21201-1757