Status:

RECRUITING

Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense

Lead Sponsor:

Zura Bio Inc

Conditions:

Hidradenitis Suppurativa (HS)

Eligibility:

All Genders

18-70 years

Phase:

PHASE2

Brief Summary

The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 16 weeks (Period 1) in adults with hidradenitis suppurativa, follow...

Eligibility Criteria

Inclusion

  • Male or female, 18 to 70 years of age
  • ≥6-month history of Hidradenitis suppurativa (HS)
  • Total AN (abscesse and inflammatory nodule) count ≥5
  • HS lesions in ≥2 distinct anatomical areas, at least one of which is Hurley Stage II or III

Exclusion

  • Draining tunnel count \>20
  • Presence of another inflammatory condition or a skin condition that may interfere with study assessments
  • Known to have immune deficiency or is immunocompromised
  • Evidence or suspicion of active or latent tuberculosis
  • History of opportunistic, chronic, or recurrent infection requiring chronic antibiotic use, serious or life-threatening infection within 2 months, or had an infection requiring systemic antibiotics within 2 weeks
  • Has active systemic candidiasis
  • Unable to tolerate subcutaneous drug administration

Key Trial Info

Start Date :

May 16 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

March 1 2027

Estimated Enrollment :

180 Patients enrolled

Trial Details

Trial ID

NCT06993610

Start Date

May 16 2025

End Date

March 1 2027

Last Update

December 11 2025

Active Locations (48)

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Page 1 of 12 (48 locations)

1

Medical Dermatology Specialists (Phoenix)

Phoenix, Arizona, United States, 85006

2

First OC Dermatology Research, Inc.

Irvine, California, United States, 92614

3

Wallace Medical Group, Inc.

Los Angeles, California, United States, 90056

4

NorCal Clinical Research

Rocklin, California, United States, 95765