Status:
RECRUITING
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
Lead Sponsor:
Dharmais National Cancer Center Hospital
Conditions:
Flap Monitoring
Inflammation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients u...
Detailed Description
Microvascular reconstructive surgery is commonly performed in cancer patients following tumor excision to restore both form and function. However, flap failure remains a major postoperative complicati...
Eligibility Criteria
Inclusion
- Adult patients (aged 18-65 years) diagnosed with cancer who are scheduled to undergo microsurgical flap reconstruction.
- Patients within the age range of 18 to 65 years at the time of enrollment.
- Patients who provide written informed consent to participate in the study.
Exclusion
- Patients with a history of uncontrolled diabetes mellitus.
- Patients diagnosed with chronic kidney disease.
- Patients with known liver failure.
- Patients receiving corticosteroid therapy prior to surgery.
- Patients with uncontrolled hypertension.
- Patients with a history of chemotherapy or radiotherapy prior to surgery.
- Patients diagnosed with preoperative sepsis.
- Patients requiring perioperative vasopressor support.
- Patients with a history of prior surgery in the same operative field.
- Patients who decline to participate in the study.
Key Trial Info
Start Date :
June 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 22 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06993740
Start Date
June 10 2025
End Date
August 22 2026
Last Update
June 15 2025
Active Locations (2)
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1
Dharmais National Cancer Center Hospital
Jakarta, DKI Jakarta, Indonesia, 11420
2
Dharmais National Cancer Center Hospital
Jakarta, DKI Jakarta, Indonesia, 11420