Status:
RECRUITING
The Vanguard Study: Testing a New Way to Screen for Cancer
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Bladder Carcinoma
Breast Carcinoma
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers i...
Detailed Description
PRIMARY OBJECTIVES: I. Assess the feasibility of recruitment and adherence to protocol-required baseline and follow-up data and blood collection. II. Assess the feasibility of achieving representati...
Eligibility Criteria
Inclusion
- Ages 45-75 years old
- Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
- Agree to allow collection of information from their medical records for study-related purposes
- Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic
- Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion
Exclusion
- Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years
- Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible
- Ongoing cancer diagnostic work-up
- Ongoing participation in another study of an investigational cancer screening test or technology
- Currently breastfeeding or pregnant, or planning to become pregnant in the next year
Key Trial Info
Start Date :
June 16 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
24000 Patients enrolled
Trial Details
Trial ID
NCT06995898
Start Date
June 16 2025
End Date
June 30 2029
Last Update
January 9 2026
Active Locations (34)
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1
Kaiser Permanente-Division of Research
Pleasanton, California, United States, 94588
2
Keefe Memorial Hospital
Cheyenne Wells, Colorado, United States, 80810
3
Kaiser Permanente-Franklin
Denver, Colorado, United States, 80205
4
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524