Status:
NOT_YET_RECRUITING
Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia
Lead Sponsor:
Assiut University
Conditions:
Community-acquired Pneumonia
Community-Acquired Infections
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute e...
Detailed Description
Community-acquired pneumonia (CAP) is a significant contributor to acute hypoxemic respiratory failure, often necessitating ventilatory support. Noninvasive ventilation (NIV) has been a conventional a...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Clinical and radiographic diagnosis of CAP
- Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen/fraction of inspired oxygen ratio (PaO₂/FiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25/min
- Informed consent obtained
Exclusion
- Hemodynamic instability requiring vasopressors
- Altered mental status Glasgow Coma Scale (GCS \< 13)
- Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery)
- Do-Not-Intubate (DNI) order
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06996834
Start Date
July 1 2025
End Date
November 1 2026
Last Update
May 30 2025
Active Locations (1)
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1
Assuit University
Asyut, Assuit, Egypt, 71515