Status:
RECRUITING
In-depth Analysis of the Immune Responses in the Upper Respiratory Tract in Older Adults Infected or Colonized With Streptococcus Pneumoniae (Spn)
Lead Sponsor:
University Hospital, Geneva
Conditions:
Pneumococcal Infections
Respiratory Syncytial Virus (RSV) Infection
Eligibility:
All Genders
60-85 years
Brief Summary
The NoseSpn-Elderly study aims at characterizing the immune response in the upper respiratory tract in adults aged 60 and over diagnosed with a pneumonia due to a Streptococcus pneumoniae (Spn) infect...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Aged 60-85 years
- Able to provide informed consent either independently or by a legal representative
- Group 1 (Spn pneumonia patients): clinical and/or radiological signs of pneumonia
- Group 1 (Spn pneumonia patients): positive Spn urinary antigen and/or blood culture and/or positive sputum test.
- Group 2 (viral respiratory infection patients): clinical signs of a respiratory infection
- Group 2 (viral respiratory infection patients): positive test for influenza or RSV
- Group 3 (asymptomatic Spn-carriers): healthy without clinical signs of infection and no lower respiratory symptoms within the last month.
- Exclusion criteria:
- Immunosuppression,
- Use of inhalation and/or nasal steroids the last month
- Intubation or under invasive mechanical ventilation
- Long-term antibiotic treatment prior to disease onset
Exclusion
Key Trial Info
Start Date :
December 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT06998251
Start Date
December 3 2024
End Date
November 1 2026
Last Update
May 31 2025
Active Locations (1)
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1
Geneva University Hospitals
Geneva, Switzerland, 1205