Status:
RECRUITING
Sodium in the Skin and Atopic Dermatitis
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Eczema
Atopic Dermatitis
Eligibility:
All Genders
50+ years
Brief Summary
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test ...
Detailed Description
The central hypothesis of this proposal is that excess dietary sodium (consumed primarily as salt) is concentrated in the skin as a physiologic response to poor barrier function, and that high levels ...
Eligibility Criteria
Inclusion
- Ages 50 years and above
- Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
Exclusion
- History of autoimmune disease.
- Cardiac events in the last six months.
- Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min).
- Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
- Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.
- (Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the criteria for severe disease.)
Key Trial Info
Start Date :
May 12 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 30 2028
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06998446
Start Date
May 12 2025
End Date
August 30 2028
Last Update
May 31 2025
Active Locations (2)
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1
San Francisco VA Medical Center
San Francisco, California, United States, 94115
2
UCSF Mt Zion Campus
San Francisco, California, United States, 94511