Status:
ACTIVE_NOT_RECRUITING
Proportional Assist Ventilation Plus and Estimation of Respiratory Effort During the Transition to Spontaneous Ventilation
Lead Sponsor:
Argentinian Intensive Care Society
Conditions:
Respiratory Effort
Proportional Assist Ventilation
Eligibility:
All Genders
18+ years
Brief Summary
In intensive care units, many critically ill patients need help from a machine called a ventilator to breathe. Once these patients start to recover, doctors try to gradually reduce this support and he...
Eligibility Criteria
Inclusion
- Adults (\>18 yrs) requiring invasive MV \>48 hrs
- Meeting spontaneous breathing transition criteria:
- Hemodynamic stability (NE \<0.1 μg/kg/min)
- Spontaneous breathing efforts
- RASS -2 to +1
- FiO₂ \<50% or PaO₂ \>60mmHg with PEEP ≤10cmH₂O
- Pre-existing esophageal balloon
- Tolerates spontaneous modes \>5 mins
- Signed informed consent
Exclusion
- Meets extubation criteria
- Hemodynamic instability
- Psychomotor agitation (RASS \>+1)
- Bronchopleural fistula
- Severe weakness (MRC \<36)
- Neuromuscular disease
- Pregnancy
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT06998927
Start Date
February 1 2024
End Date
June 30 2025
Last Update
June 8 2025
Active Locations (1)
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1
Hospital Británico de Buenos Aires
CABA, Buenos Aires, Argentina