Status:
RECRUITING
Imaging Studies in Corticobasal Syndrome
Lead Sponsor:
Jennifer Whitwell
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Cortico Basal Degeneration
Corticobasal Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will ...
Detailed Description
Corticobasal syndrome (CBS) is a neurodegenerative disorder characterized by cognitive and behavioral change, as well as asymmetric parkinsonism, dystonia, myoclonus, and limb apraxia. Emerging eviden...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Meet possible or probable CBS criteria
Exclusion
- Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)
- Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome
- Subjects will be excluded if they have a mutation in the progranulin gene
- Subjects will excluded if they have received anti-Aβ therapy
- Women who are pregnant will be excluded
- Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)
- Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid/glucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning
Key Trial Info
Start Date :
June 25 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2031
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07000851
Start Date
June 25 2025
End Date
March 30 2031
Last Update
July 7 2025
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905