Status:
RECRUITING
Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study
Lead Sponsor:
Kasr El Aini Hospital
Conditions:
Ketamine-dexmedetomidine Induction of Anesthesia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
To compare the hemodynamic effects of Ketamine-Dexmedetomidine admixture (Ketodex) versus propofol-ketamine admixture (Ketofol) during induction of anesthesia in elderly
Detailed Description
This study details the protocol for anesthetic induction and maintenance, allocating patients into Ketodex (KD) and Ketofol (KP) groups. Prior to anesthesia, a fluid challenge (4 mL/kg over 10 minutes...
Eligibility Criteria
Inclusion
- Elderly patients (\>65 years)
- ASA physical status I-III
- Elective non-cardiac surgery under general anesthesia.
Exclusion
- Patients with severe cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent \[MET\] less than 4
- Patients on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers medications
- Patients with uncontrolled hypertension
- patients undergoing adrenalectomy
- patients with body mass index \<18 or \> 35 kg/m²
- patient with allergy to any of the study drugs.
- patient is considered to be a difficult intubation in the preoperative assessment.
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 15 2026
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT07002073
Start Date
January 1 2025
End Date
February 15 2026
Last Update
December 17 2025
Active Locations (1)
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1
Cairo University Hospitals
Cairo, Giza Governorate, Egypt