Status:
RECRUITING
Identifying the Limits of Survivability in Heat-exposed Older Females
Lead Sponsor:
University of Ottawa
Conditions:
Heat Stress
Temperature Change, Body
Eligibility:
FEMALE
65-85 years
Phase:
NA
Brief Summary
Climate change increases extreme heat events, elevating global heat-illness risk. Females have reduced heat loss capacity (\~5%) compared to males, driven by differences in skin blood flow and sweatin...
Eligibility Criteria
Inclusion Criteria:
- Non-smoking.
- English or French speaking.
- Ability to provide informed consent.
- With or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis
Exclusion Criteria:
- Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).
- Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).
- Uncontrolled hypertension - BP >150 mmHg systolic or >95 mmHg diastolic in a sitting position.
- Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).
- Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.
- Cardiac abnormalities identified during screening
Key Trial Info
Start Date :
July 16 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT07032493
Start Date
July 16 2025
End Date
January 31 2026
Last Update
November 28 2025
Active Locations (2)
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1
University of Ottawa
Ottawa, Ontario, Canada, K1N6N5
2
University of Ottawa
Ottawa, Ontario, Canada