Inclusion Criteria:

• Patients aged > 18 years
• Patients capable of providing informed consent
• Unilateral total knee replacement surgery
• Indication for surgery: primary osteoarthritis degeneration
• Surgery performed electively

Exclusion Criteria:

• Patients aged < 18 years
• Patients incapable of providing informed consent
• Patients with ASA class > 3
• Pregnant women
• Patients with rheumatoid arthritis or other autoimmune disorders
• Patients with active infection under antibiotic treatment
• Patients on chronic opioid therapy
• Patients on chronic biological drug therapy
• Patients with a history of corticosteroid use in the six months prior to surgery
• Patients with a history of periarticular infiltration in the three months prior to surgery
• Patients in whom loco-regional anesthesia is contraindicated
• Patients in whom NSAID, cortisone, and paracetamol therapy is contraindicated
• Bilateral total knee replacement surgery or prosthetic revision surgeries
• Indication for surgery for causes other than primary osteoarthritis degeneration