Status:
RECRUITING
STICH3C Cardiac Magnetic Resonance Observational Study
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Ischemic Left Ventricle Systolic Dysfunction
Multivessel Coronary Artery Disease
Eligibility:
All Genders
18+ years
Brief Summary
STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovas...
Detailed Description
iLVSD (ischemic left ventricular dysfunction) is a leading cause of heart failure (HF) and death. It is widely treated via coronary revascularization despite limited understanding of determinants of r...
Eligibility Criteria
Inclusion
- Men and women ≥ 18 years old
- LVEF ≤ 40% (quantified by echo, single-photon emission computed tomography \[SPECT\], or CMR within 2 months of enrollment)
- Prognostically important CAD: either multivessel CAD (triple vessel or double vessel CAD including left anterior descendant artery (LAD), significant coronary stenosis defined as ≥ 70% based on coronary angiography, fractional flow reserve (FFR) ≤ 0.80 or instantaneous wave-free ratio (iFR) ≤ 0.89) or left main disease (+/- other CAD) for which significant stenosis defined as \> 50% based on coronary angiography, intravascular ultrasound (IVUS) minimum luminal area \[MLA\] value ≤ 6.0 mm2 (\< 4.5 mm2 Asian descent), or equivalent optical coherence tomography (OCT) measurements.
- Planned CABG or PCI within 3 months
Exclusion
- Concomitant valve disease or other condition (e.g., LV aneurysm) requiring surgical repair or replacement
- Contraindication to CMR (i.e. magnetically activated materials), gadolinium, regadenoson/adenosine/dipyridamole
- Active neoplasm and/or severe end-organ dysfunction with expected life expectancy less than 5 years.
- \-
Key Trial Info
Start Date :
March 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07133984
Start Date
March 1 2024
End Date
January 1 2030
Last Update
August 21 2025
Active Locations (9)
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1
NewYork-Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States, 11215
2
New York Presbyterian - Queens
Flushing, New York, United States, 11355
3
Weill Cornell Medicine/NewYork Presbyterian Hospital
New York, New York, United States, 10022
4
MU Vienna Austria
Vienna, Austria