Status:
NOT_YET_RECRUITING
Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility Study
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Sarcopenia
Prostate Cancer
Eligibility:
MALE
65+ years
Brief Summary
To find out whether it is possible to run a study looking at the underlying markers of ageing in muscle quality and quantity in men receiving Androgen Deprivation Therapy for prostate cancer treatment...
Detailed Description
Androgen Deprivation Therapy (ADT) is a well-established therapy for prostate cancer that improves overall survival rates, reduced rates of metastatic prostate cancer and death from prostate cancer . ...
Eligibility Criteria
Inclusion
- Age ≥65 years old at time of recruitment
- Able to provide informed consent to participate
- Known prostate cancer due to be initiated on ADT for the first time (with or without Androgen Receptor Targeted Agents (ARTA) or radiotherapy), or initiated within two weeks prior to recruitment.
- Individuals involved in other research will be eligible to participate so long as the other research does not involve potential changes to the standard ADT care the participant will be receiving and does not involve an intervention aimed at reducing the muscle atrophy associated with ADT.
Exclusion
- Systemic anti-cancer therapy within one year of recruitment (for prostate cancer or any other concomitant cancer)
- Planned surgery (not including eye surgery or other minor surgery) within six months of ADT
- Any other condition previous or current which, in the judgement of the responsible clinician, is likely to interfere with the trial / assessments.
- Lacks capacity to consent
- Exclusion criteria for those consenting to optional muscle biopsy:
- On treatment with clopidogrel, high-dose aspirin, dipyridamole or anticoagulants
- Known bleeding disorder or platelets \<75x103/mL
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07134439
Start Date
September 1 2025
End Date
December 1 2026
Last Update
August 21 2025
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