Status:
RECRUITING
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
Lead Sponsor:
Peking University Shenzhen Hospital
Conditions:
Cognitive and Behavioral Impairment
Eligibility:
All Genders
60+ years
Brief Summary
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative ...
Detailed Description
This is a single-center, prospective, single-arm cohort study designed to estimate the incidence of postoperative cognitive decline (POCD) in patients aged 60 years and older with preexisting cognitiv...
Eligibility Criteria
Inclusion
- Preexisting Cognitive Impairment (PreCI) Surgical Group
- Age ≥ 60 years
- Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia
- Undergoing elective non-cardiac surgery under general anesthesia
Exclusion
- Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)
- Usual residence outside Shenzhen
- Normative Reference Group
- Inclusion Criteria:
- Age ≥ 60 years
- No history of general anesthesia surgery within the past 12 months
- Mini-Cog score \> 1
Key Trial Info
Start Date :
July 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
340 Patients enrolled
Trial Details
Trial ID
NCT07135336
Start Date
July 15 2025
End Date
July 1 2027
Last Update
August 22 2025
Active Locations (1)
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1
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China