Status:
COMPLETED
Clinical and Biochemical Effects Of Cryotherapy Protocols On Mandibular Premolars With Symptomatic Apical Periodontitis
Lead Sponsor:
Ain Shams University
Conditions:
Post Operative Pain
Inflammation
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Pain is the major reason for patients' visits to dental clinics.Medications have side effects. Treatments including cryotherapy have been suggested to prevent these side effects.This study will compar...
Detailed Description
-Oral Cryo Group: All patients will receive anesthesia containing Artinibsa 4%:100,000 epinephrine (Inibsa, Spain) 1.8 mL . The teeth will be isolated with a rubber dam (Sanctuary) after local anesth...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Both genders
- Eligible participants will be between the ages of 18-45
- Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study
- Having a mandibular single rooted premolar tooth with vital pulp Vertucci Type I canal system.
- Patients that will be diagnosed with symptomatic apical periodontitis on the basis of the clinical symptoms of severe preoperative pain (visual analogue scale \[VAS\] \> 7) and severe percussion pain (VAS \> 7)
- The absence of periapical radiolucency on x ray.
- Exclusion criteria :
- Presence of any systemic disease or allergic reactions
- Vulnerable population: prisoners, pregnant women, mentally ill people, etc.
- Use of analgesic or antibiotic medication within seven days
- A radiographically untraceable canal
- Excessively curved root
- Excessively long or short root length
- Teeth with open apices
- A previous root canal treatment
- Sinus tracts
- Local gum swelling around the affected tooth
- Severe periodontal disease
- Presence of periodontal pockets \>3 mm in the affected tooth
- Absence of bleeding in the pulp chamber on access cavity preparation
- Problems in determining working length
- Broken files, over instrumentation, and overfilling/incomplete filling
Exclusion
Key Trial Info
Start Date :
June 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07138365
Start Date
June 1 2024
End Date
June 1 2025
Last Update
August 22 2025
Active Locations (1)
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1
Ain Shams University
Cairo, Egypt