Status:
RECRUITING
Safty and Efficacy of MCI Network Guided TMS for Early Alzheimer's Disease: A Randomized, Double-blind Trial
Lead Sponsor:
Anhui Medical University
Conditions:
Alzheimer's Disease
Transcranial Magnetic Stimulation
Eligibility:
All Genders
45-85 years
Phase:
NA
Brief Summary
Estimate the safty and efficacy of personalized network neuronavigated transcranial magnetic stimulations in early Alzheimer's disease patients
Detailed Description
All patients undergo a series of medical assessments that include physical examination and routine laboratory studies before and after repetitive transcranial magnetic stimulation (rTMS) treatment. Up...
Eligibility Criteria
Inclusion
- Subject diagnosed as either mild cognitive impairment due to AD or mild AD dementia based on National Institute on Aging-Alzheimer's Association criteria.
- MMSE score 18-28.
- CDR score 0.5-1.
- On stable treatment with IAChE or memantine for at least 6 months.
- Literate in Han Chinese.
Exclusion
- Recevied rTMS treatment in the past 3 months.
- Depression or other psychiatric disorders.
- History of head injury, stroke, epilepsy or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of unexplained loss of consciousness.
- Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, or any implanted medical device that is incompatible with MRI.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Key Trial Info
Start Date :
July 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07138677
Start Date
July 20 2025
End Date
December 30 2025
Last Update
September 15 2025
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230000