Status:
RECRUITING
Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCS
Lead Sponsor:
University of Haifa
Collaborating Sponsors:
Loewenstein Hospital
Reuth Rehabilitation Hospital
Conditions:
Phantom Limb Pain After Amputation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of ch...
Detailed Description
Approximately 80% of amputees experience PLP, often severe, for years after amputation and most amputees will experience phantom limb sensations, including kinetic, proprioceptive (i.e. feeling of len...
Eligibility Criteria
Inclusion
- Adults (age ≥18);
- Amputation of a single limb ≤12 weeks ago; during this period of time, 80% of amputees develop PLP. Both upper and lower limb amputees are included to increase feasibility;
- Acute PLP stage (2 weeks since first report), with intensity ≥3 on a 0-10 VAS;
- No change in medication in past week, excluding pro re nata analgesics;
- Can understand the study's purpose and instructions;
- Agrees to participate and to provide written informed consent.
Exclusion
- Stump wound not healed;
- Other psychological, psychiatric, or neurological conditions;
- Contraindications for tDCS or magnetic resonance imaging (MRI) (MRI data will not be analyzed in the proposed PhD project), including previous seizure, loss of consciousness due to head injury, metal in the head, implanted devices, claustrophobia, a skin condition or an unhealed wound on the scalp, and possibility of being pregnant;
- Inability to provide informed consent or understand or carry out the experiment.
Key Trial Info
Start Date :
March 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2029
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT07139483
Start Date
March 25 2025
End Date
March 1 2029
Last Update
September 8 2025
Active Locations (3)
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1
Loewenstein Hospital
Raanana, Israel, Israel, Ahuza 278
2
Reut Medical Center
Tel Aviv, Israel, Israel
3
Sheba Medical Center
Tel Aviv, Israel