Status:
RECRUITING
Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment
Lead Sponsor:
University of Pavia
Conditions:
Peri-implant Mucositis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This randomized controlled clinical trial investigates the effectiveness of trehalose powder compared to glycine powder when used in air-polishing during supportive therapy for peri-implant mucositis,...
Detailed Description
Peri-implant mucositis is a reversible inflammatory condition affecting the soft tissues surrounding dental implants and represents an early stage in the progression toward peri-implantitis if left un...
Eligibility Criteria
Inclusion
- Adults aged between 18 and 70 years
- Presence of peri-implant mucositis, defined as bleeding on probing (BoP) around implants without radiographic evidence of bone loss beyond initial remodeling
- Visible biofilm on implant surfaces
- Ability to understand and sign informed consent
- Good oral hygiene and patient compliance
- Availability for all follow-up visits (1, 3, and 6 months)
Exclusion
- Presence of systemic conditions that may affect healing (e.g., uncontrolled diabetes, immunosuppression)
- Current smokers or former smokers who quit less than 6 months ago
- Pregnant or breastfeeding women
- Use of antibiotics or anti-inflammatory drugs in the 3 months prior to baseline
- Presence of peri-implantitis (i.e., bleeding on probing with concomitant radiographic bone loss)
- History of head and neck radiotherapy
- Presence of pacemakers or cardiac stimulators
- Neurological or psychological disorders affecting study compliance
Key Trial Info
Start Date :
August 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 10 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07140146
Start Date
August 30 2025
End Date
March 10 2026
Last Update
September 16 2025
Active Locations (1)
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1
Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Lombardy, Italy, 27100