Status:
COMPLETED
Analysis of Influence Factors on Osteopenia in Different Treatment of Psoriasis
Lead Sponsor:
Chongli Yu
Conditions:
Psoriasis
Eligibility:
All Genders
18+ years
Brief Summary
This clinical study aims to evaluate and compare changes in bone mineral density (BMD) and bone metabolism markers in patients with moderate-to-severe psoriasis treated with either Secukinumab or Adal...
Detailed Description
Psoriasis is a chronic, immune-mediated inflammatory skin disease associated with increased systemic inflammation, which may contribute to altered bone metabolism and decreased bone mineral density (B...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Adults aged 18 years or older.
- Clinically confirmed diagnosis of psoriasis (with or without psoriatic arthritis).
- Currently receiving one of the following treatments: TNF-α inhibitor (adalimumab), or IL-17A inhibitor (secukinumab).
- Able and willing to undergo bone mineral density (BMD) assessment using dual-energy X-ray absorptiometry (DXA).
- Signed informed consent provided. Exclusion Criteria
- History of other systemic diseases affecting bone metabolism (e.g., primary hyperparathyroidism, severe chronic kidney disease, Cushing's syndrome).
- Current use of medications known to strongly affect bone metabolism (e.g., long-term corticosteroids, bisphosphonates, denosumab, teriparatide).
- Pregnant or breastfeeding women.
- History of malignancy or other autoimmune diseases requiring systemic immunosuppressive therapy.
- Inability to complete study visits, assessments, or provide informed consent.
Exclusion
Key Trial Info
Start Date :
August 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 28 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07140666
Start Date
August 1 2022
End Date
December 28 2022
Last Update
September 2 2025
Active Locations (1)
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1
Chinese PLA General Hosptial
Beijing, Beijing Municipality, China, 100853