Status:
RECRUITING
Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment
Lead Sponsor:
Al-Azhar University
Conditions:
Previous Endodontic Treatment Failure and Radiographically Confirmed Periapical Radiolucency
Eligibility:
MALE
20-40 years
Phase:
NA
Brief Summary
The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue thro...
Detailed Description
Diode laser exhibits a powerful antibacterial effect by altering the bacterial cell wall and damaging the cell membrane. Its photothermal action targets accessible bacteria, while its photodisruptive ...
Eligibility Criteria
Inclusion
- Patients have single-rooted teeth with root canal form type I.
- Have previous endodontic therapy with failure.
- Have periapical radiolucency (PAI score of 3 or 4).
- Asymptomatic patients who had no pain or swelling had a negative response to palpation and percussion.
- Patients who provide written informed consent.
Exclusion
- Patients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation.
- Systemic disease.
- Physical or mental disability.
- Non restorable teeth.
- Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly
Key Trial Info
Start Date :
August 18 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 20 2026
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT07141459
Start Date
August 18 2025
End Date
October 20 2026
Last Update
September 4 2025
Active Locations (1)
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1
from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt