Status:
ENROLLING_BY_INVITATION
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
Lead Sponsor:
Beth Israel Deaconess Medical Center
Conditions:
VA-ECMO
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP...
Detailed Description
The investigators hypothesize that an individualized PEEP titration guided by esophageal pressure measurements and Electrical Impedance Tomography can reduce lung overdistention, enhance lung recruitm...
Eligibility Criteria
Inclusion
- Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure.
- On ECMO support for at least 6 hours
- Swan-Ganz catheter required as standard clinical care
- Clinically stable in the estimation of the study investigator
Exclusion
- Contraindications to EIT (e.g., presence of pacemaker or IMPELLA device for electrical interference)
- Patients without pulmonary flow (non-pulsatile pulmonary prSessure)
- Patients with known pulmonary embolism
- Imminent withdrawal of life support
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2027
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT07141524
Start Date
December 1 2025
End Date
February 28 2027
Last Update
November 17 2025
Active Locations (2)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215