Status:
NOT_YET_RECRUITING
Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Venous Thromboembolism (VTE)
Exercise Therapy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite st...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days
- Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission
- Written informed consent
Exclusion
- Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)
- Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)
- Recently completed (i.e., \<6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication
- Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)
- Contraindication to anticoagulation
- Life expectancy \<1 year based on the treating physician's clinical judgement
- Known pregnancy
- Inability to speak German or French
- Participation in another study that prohibits concurrent participation in RehabPE
- Unable to provide informed consent (e.g., due to dementia)
- Unwilling to provide informed consent
- Prior enrollment in this study
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT07143539
Start Date
October 1 2025
End Date
March 1 2028
Last Update
August 27 2025
Active Locations (1)
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1
Inselspital, Bern University Hospital
Bern, Switzerland, 3010