Status:
COMPLETED
Topical Hyaluronic Acid Adjunctive Effects on Healing After Free Gingival Grafting in Smokers and Non-Smokers
Lead Sponsor:
Istanbul University
Collaborating Sponsors:
Ricerfarma S.r.l
Conditions:
Recession, Gingival
Tissue Grafts
Eligibility:
All Genders
18-65 years
Brief Summary
Comparison of the healing of free gingival grafts applied to smokers and non-smokers and evaluation of the effect of hyaluronic acid gel on healing of the donor site.
Detailed Description
The oral mucosa consists of three main components: (1) masticatory mucosa, (2) specialized mucosa, and (3) lining mucosa. The masticatory mucosa is a keratinized tissue covering the gingiva and the ha...
Eligibility Criteria
Inclusion
- Patients were eligible for inclusion if they were between 18 and 65 years of age, systemically healthy, and not taking regular medication. Additional criteria included the absence of antibiotic use within the last three months, no pregnancy or lactation, a periodontally healthy status or completion of periodontal therapy, and the presence of insufficient keratinised gingiva in the mandibular anterior region (canine-to-canine) with a clinical indication for FGG in the same area. Smoking and non-smoking status were determined from clinical records and patient self-reports. All smokers included in the study continued smoking throughout the documented postoperative period, and none of the non-smokers had a history of smoking or initiated smoking during the study period.
Exclusion
- Subjects who do not meet these conditions will not be included in the study.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07143760
Start Date
January 1 2018
End Date
November 30 2022
Last Update
August 27 2025
Active Locations (1)
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1
Istanbul University, Dentistry Faculty, Department of Periodontology
Istanbul, Turkey (Türkiye), 34116