Status:
NOT_YET_RECRUITING
Enhancing Slow Wave Sleep in Depression
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Depression - Major Depressive Disorder
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression. It will also determine if increased deep sleep improves c...
Detailed Description
The purpose of this pilot study is to determine if non-invasive transcranial electrical stimulation (TES) delivered during slow-wave sleep (SWS) can enhance this stage of sleep in people with depressi...
Eligibility Criteria
Inclusion
- Ability to complete overnight sleep study including placement of EEG leads
- Ability to read and understand English.
- Moderate depression
- Self-reported cognitive complaints
Exclusion
- Previous adverse reaction to transcranial electrical stimulation
- Presence of implanted devices (e.g. intracranial device, cochlear implant)
- Presence of metal in head (e.g. surgical clip)
- Sensitivity or allergy to silver
- Presence of significant neurologic disease (e.g. Parkinson's disease, epilepsy/seizure disorder, severe migraine disorder)
- History of significant head trauma
- History of stroke or other ischemic event
- Diagnosed with schizophrenia, bipolar disorder, substance use disorder, or presence of current suicidal ideation
- Currently taking medications that could alter EEG or cognitive function
- Presence of severe insomnia
- Presence of severe, untreated sleep apnea
- Currently pregnant
- Planned travel outside time zone during the study
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT07143838
Start Date
January 1 2026
End Date
December 1 2026
Last Update
December 17 2025
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27104