Status:
COMPLETED
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
Lead Sponsor:
Imam Abdulrahman Bin Faisal University
Conditions:
Cross Infection (Hospital-Acquired Infections)
Critical Illness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients. ICU-AIs are ...
Eligibility Criteria
Inclusion
- Enrolled patients were critically ill adults aged 18 years or older, had initiated enteral nutrition (EN) within 48 hours of ICU admission, were required mechanical ventilation and were anticipated to remain ventilated for at least five days.
Exclusion
- Patients were excluded if they had been mechanically ventilated for more than 72 hours before enrollment; had an absolute neutrophil count under 500/mm³; had received antibiotics for more than three days before screening; had received immunosuppressants within one week prior to enrollment or had a diagnosis of immunosuppressive disease; had end-stage cancer; had previously received probiotics, prebiotics, or synbiotics before screening; were pregnant or lactating; or had not received the first dose of probiotics within 48 hours following ICU admission.
Key Trial Info
Start Date :
February 13 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 29 2024
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT07144124
Start Date
February 13 2024
End Date
September 29 2024
Last Update
August 27 2025
Active Locations (1)
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1
King Fahad Military Medical Complex
Dhahran, Eastern Province, Saudi Arabia