Status:
NOT_YET_RECRUITING
Comparison of Milrinone and Epinephrine on TAPSE
Lead Sponsor:
Mansoura University
Conditions:
Cardiac Anaesthesia
Cardiopulmonary Bypass
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures. it has significan...
Detailed Description
Epinephrine is the most potent adrenergic agonist which has positive inotropic and chronotropic effects and enhanced conduction in the heart (β1), smooth muscle relaxation in the vasculature and bronc...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) physical status II \& III
- Age between 18 and 70 years
- Both Gender
- Body mass index less than 40 kg/m2
- Ejection fraction of \>40%
- Tricuspid annular plane systolic excursion (TAPSE) \< 1.7cm
Exclusion
- Patient refusal.
- Preoperative RV impairment
- Pulmonary hypertension (estimated pulmonary artery systolic pressure \> 50 mmHg)
- Patients with any contraindications to Transesophageal echocardiography (TEE)
- Redo or Re-exploration surgery
- Patients with chronic kidney disease (serum creatinine \> 1.5 mg/ dl)
- Patients with chronic liver disease (child pugh B and C)
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 30 2027
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT07144267
Start Date
October 1 2025
End Date
March 30 2027
Last Update
September 29 2025
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