Status:
ENROLLING_BY_INVITATION
Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures
Lead Sponsor:
University of California, Irvine
Conditions:
Rib Fractures
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Rib fractures cause a significant amount of pain and are associated with an increased risk of lung infections, long hospitalization, and increased cost. Effective pain control is the cornerstone of ma...
Detailed Description
Rib fractures are a common and painful injury associated with increased risk of pneumonia, prolonged hospitalization, and higher healthcare utilization. In a national database review, rib fractures we...
Eligibility Criteria
Inclusion
- \> 18 years old
- Blunt trauma patients
- \> 3 rib fractures
- Able to tolerate oral intake
Exclusion
- \< 17 years old
- Pregnant
- Prisoners
- History of adverse reaction to suzetrigine
- Current strong CYP3A inhibitor medication use
- o Strong Inhibitors: clarithromycin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, atazanavir, darunavir, indinavir, lopinavir, telithromycin
- Current strong or moderate CYP3A inducer
- Strong Inducers: apalutamide, carbamazepine, encorafenib, enzalutamide, fosphenytoin, lumacaftor and ivacaftor, mitotane, phenytoin, rifampin
- Moderate Inducers: bexarotene (Systemic), bosentan, cenobamate, dabrafenib, dipyrone, efavirenz, elagolix, estradiol, and norethindrone, eslicarbazepine, etravirine, fexinidazole, lorlatinib, mitapivat, modafinil, nafcillin, pacritinib, pexidartinib, phenobarbital, primidone, repotrectinib, rifabutin, rifapentine, sotorasib, St John's Wort
- Cirrhosis
- GCS \< 14
- Rhabdomyolysis (CPK \> 5,000 U/L)
- Chronic opioid use (\>30mg OME/day)
- Known or suspected active infection with human immunodeficiency virus or hepatitis B or C viruses
Key Trial Info
Start Date :
November 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07145346
Start Date
November 13 2025
End Date
August 1 2027
Last Update
December 8 2025
Active Locations (1)
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1
University of California, Irvine
Orange, California, United States, 92868