Status:
RECRUITING
Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Lead Sponsor:
Adam Frank
Conditions:
Obsessive - Compulsive Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants w...
Detailed Description
This is a randomized, controlled pilot study to evaluate the feasibility, tolerability, and preliminary effects of combining repetitive transcranial magnetic stimulation (rTMS) with one of two types o...
Eligibility Criteria
Inclusion
- Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria.
- Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks.
- Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions)
- Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD
- Willing to maintain psychotropic medication levels throughout the 16 weeks of the study
Exclusion
- Primary psychiatric diagnosis other than OCD
- Active substance use disorder
- Active suicidality
- Active psychosis
- History of seizures
- Severe neurological impairment
- Pregnant or planning to become pregnant
- Received a prior rTMS course
Key Trial Info
Start Date :
November 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT07146438
Start Date
November 10 2025
End Date
August 1 2028
Last Update
October 27 2025
Active Locations (1)
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1
University of Southern California Health Sciences Campus
Los Angeles, California, United States, 90033