Status:
NOT_YET_RECRUITING
Multimodal PET Imaging With 18F-FDG/SV2A/TSPO for Resection Planning in Drug-Resistant Epilepsy
Lead Sponsor:
Weibing Miao, PhD
Conditions:
Epilepsy
PET / MR
Eligibility:
All Genders
18-50 years
Brief Summary
This study focuses on the application value of 18F-FDG, SV2A, and TSPO PET imaging in the preoperative localization of epileptogenic foci in epilepsy. 18F-FDG PET detects glucose metabolism in brain t...
Eligibility Criteria
Inclusion
- with drug-resistant focal epilepsy defined by ILAE criteria
- Already performed 3.0 T epilepsy-protocol MRI and video-EEG
- Planned resective surgery or stereotactic EEG (SEEG) electrode implantation, and willingness to undergo all three PET scans: ¹⁸F-FDG, SV2A, and TSPO.
- Ability to understand study procedures and provide written informed consent.
- Availability of complete postoperative follow-up data with at least 12-month Engel outcome classification.
Exclusion
- History of head trauma ,claustrophobia, rheumatic or autoimmune diseases, psychiatric disorders, severe somatic diseases (neurological,cardiovascular, etc.),previous heart or brain surgery, substance abuse, inability to refrain from hypnotics, magnetic implants, pregnancy, lactation
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2029
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07147309
Start Date
September 1 2025
End Date
September 1 2029
Last Update
August 29 2025
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