Status:
NOT_YET_RECRUITING
Assessing How the Body Responds to Increased Phosphate Intake, and How This Response Depends on Age and Sex.
Lead Sponsor:
University of Zurich
Conditions:
Aging
Kidney Disease
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
Kidney function declines with age and this could affect phosphate balance after an acute phosphate load (increased phosphate intake). In daily life, we regularly experience acute phosphate loads throu...
Detailed Description
Forty subjects (males and females aged 18-25 or 63-70) will ingest an oral phosphate load, after which their body's response will be assessed by collecting blood and urine samples over a period of ten...
Eligibility Criteria
Inclusion
- Healthy volunteers 18-25 and 63-70 years old
- 5 ≥ BMI \< 26 kg/m2
- 84 ≥ phosphate in plasma ≤ 1.45 mM
- 20 ≥ calcium in plasma ≤ 2.50 mM
- 15 ≥ PTH in plasma ≤ 65 pg/ml
- eGFR ≥ 60 ml/min/1-73 m2
- 90 ≥ Systolic blood pressure ≤ 140 mmHg
- 60 ≥ Diastolic blood pressure ≤ 85 mmHg
- No hematuria and no acute urinary tract infection
- Ability and willingness to participate in the study
- Voluntary signed inform consent
Exclusion
- Diabetes mellitus
- Pregnancy
- History of kidney stones
- History of parathyroidectomy
- History of anorexia nervosa
- History of bulimia
- History of solid organ transplantation.
- Nephrolithiasis
- Sarcoidosis
- Chronic pancreatitis
- Chronic diarrhea
- Chronic liver disease
- Complete distal renal acidosis (dRTA)
- Cystinuria
- Hypo- or hyperaldosteronism
- Hyper- or hypotension
- Hypernatremia
- Gastrointestinal disorders
- Known hypersensitivity reactions to azoic dyes, acetylsalicylic acid, as well as antirheumatic drugs and painkillers (prostaglandin synthesis inhibitors).
- Intake of vitamin D and calcium supplements, phosphate, bisphosphonates, cinacalcet, denusomab, teriparatide, systemic glucocorticoids or mineralcorticoids, antiepileptics, carboanydrase inhibitors or diuretics
Key Trial Info
Start Date :
September 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07149337
Start Date
September 30 2025
End Date
September 1 2027
Last Update
September 2 2025
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