Status:
RECRUITING
Continuous Effect Of Rehabilitation Training On Pulmonary Arterial Hypertension Patients
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Shanghai Pulmonary Hospital, Shanghai, China
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Pulmonary Hypertension
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This multicenter, open label, double-arm study aims at investigating the the continuous effect of long-Term rehabilitation training on clinical improvement(ITTCI) and cardiopulmonary function in pulmo...
Detailed Description
Pulmonary Arterial Hypertension (PAH) is a disease caused by various reasons leading to pulmonary vascular remodelling and then results in a progressive increase in pulmonary vascular resistance and r...
Eligibility Criteria
Inclusion
- Patients who suffered from pre-capillary PAH (mPAP ≥ 20 mmHg, PVR \> 2 Woods unit, PAWP ≤ 15 mmHg) confirmed by right heart catheterisation.
- Patients who are in the status of WHO-FC I-III.
- Patients between 18 and 75 years old
- Female subjects are not pregnant.
- Patients are treated with PAH-targeted drugs and are in a stable state and there is no progress of disease).
- Patients have not received exercise rehabilitation training within six months.
Exclusion
- Patients with the following diseases or symptoms:
- Pulmonary vascular occlusive disease
- Respiratory diseases
- Ischaemic heart disease, complex congenital heart disease (e.g., tetralogy of Fallot, etc.), cardiomyopathy, valvular disease
- Active liver disease
- Severe kidney disease
- Motor disorders (e.g. lower limb fracture, ataxia, etc.)
- Malignant tumour diseases
- Physical disability
- Hb ≤ 80g / L
- Systolic blood pressure ≤85mmHg
- History of syncope within 3 months
- History of supraventricular or ventricular arrhythmia at rest within 3 months.
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT07149935
Start Date
September 1 2024
End Date
December 1 2026
Last Update
September 2 2025
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 210007