Status:
NOT_YET_RECRUITING
Intraoperative Lidocaine Infusion
Lead Sponsor:
Assiut University
Conditions:
Enhanced Recovery After Anesthesia
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
PHASE3
Brief Summary
This study aims to evaluate the analgesic and anti-inflammatory effect of perioperative intravenous lidocaine infusion and in turn the return of gastric motility in patients undergoing elective laparo...
Detailed Description
Laparoscopic cholecystectomy is considered a minimally invasive procedure; however, it still provokes a measurable systemic inflammatory response. This reaction is primarily driven by factors such as ...
Eligibility Criteria
Inclusion
- Patients aged 18 - 60 years
- Elective laparoscopic cholecystectomy for symptomatic cholelithiasis or chronic cholecystitis
- ASA physical status I-II
- BMI \< 35 kg/m2
- Preoperative CRP \<20 mg/L
- Informed consent provided
Exclusion
- Acute cholecystitis or biliary pancreatitis
- Conversion to open surgery
- Pre-op CRP \>20 mg/L
- Allergy to lidocaine or local anesthetics
- Known hepatic or renal dysfunction
- Chronic inflammatory conditions
- Current immunosuppressive therapy
- Cardiac arrhythmias or heart block without pacemaker
- ASA physical status III, IV or above
- Pregnancy or breastfeeding
- Psychiatric disorders
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT07150481
Start Date
October 1 2025
End Date
March 1 2027
Last Update
September 2 2025
Active Locations (1)
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1
Assiut university main hospital
Asyut, Assiut Governorate, Egypt,, Egypt, 71515