Status:
RECRUITING
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
Lead Sponsor:
Beijing Anzhen Hospital
Collaborating Sponsors:
Yan'an Affiliated Hospital of Kunming Medical University
Xiangya Hospital of Central South University
Conditions:
Acute Type A Aortic Dissection
Hypothermia
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals ...
Eligibility Criteria
Inclusion
- Aortic CTA confirmed as ATAAD according to the 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease;
- Adult patients (18-70 years) weighing 50-120 kg;
- Time interval between the onset of symptoms and operation is less than 14 days;
- Indications for total aortic arch replacement are available;
- Signed informed consent and availability for follow-up.
Exclusion
- History of chronic renal failure, hepatocirrhosis, and hepatic insufficiency;
- Severe gastrointestinal complications of non-aortic dissection, such as mesenteric ischemia, gastrointestinal bleeding, hepatopancreaticobiliary dysfunction, and intestinal obstruction;
- History of severe cerebral infarction (with cerebral infarction sequels);
- Preoperative intubation or unconsciousness;
- Inflammatory aortic diseases, such as Takayasu arteritis and Behçet's disease, etc;
- History of infectious aortic diseases;
- History of cardiac and aortic surgery;
- History of malignancy or previous radiotherapy;
- Pregnant or feeding women, or anyone planning to reproduce during the test period;
- Without an informed consent signature;
- Participating in any other clinical trial;
- Having other causes not eligible for operation.
Key Trial Info
Start Date :
February 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2028
Estimated Enrollment :
306 Patients enrolled
Trial Details
Trial ID
NCT07150559
Start Date
February 1 2026
End Date
February 28 2028
Last Update
December 15 2025
Active Locations (1)
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1
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China, 100013