Status:
NOT_YET_RECRUITING
Development of an Early Warning Model for Intensive Care Unit-Acquired Weakness in Mechanically Ventilated Children: A Disease-Specific Cohort and Database Study
Lead Sponsor:
Children's Hospital of Fudan University
Conditions:
ICU Acquired Weakness
Eligibility:
All Genders
1-18 years
Brief Summary
Acquired weakness (AW) is a common complication among patients in the Intensive Care Unit (ICU). It is a systemic muscle weakness and dysfunction associated with critical illness, often related to pro...
Detailed Description
A prospective cohort study of mechanically ventilated children was established to systematically analyze epidemiological characteristics. The modified Pediatric Medical Research Council (MRC) muscle s...
Eligibility Criteria
Inclusion
- Age between 28 days and 18 years;
- Patients continuously admitted to the PICU during the study period and subjected to invasive mechanical ventilation.
Exclusion
- Mechanical ventilation duration \< 72 hours;
- Presence of primary central or neuromuscular diseases that significantly affect central or peripheral respiratory failure, including: traumatic brain injury, cerebrovascular disease history (e.g., cerebral hemorrhage, cerebral infarction), intracranial tumors, central nervous system infections, spinal cord injury, Guillain-Barré syndrome, porphyria, paraneoplastic neuropathy, etc.;
- Conditions requiring immobilization such as limb joint surgery or fractures.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2028
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT07150637
Start Date
September 1 2025
End Date
September 30 2028
Last Update
September 2 2025
Active Locations (1)
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1
Children' hospital of Fudan university
Shanghai, Shanghai Municipality, China, 201102