Status:
COMPLETED
Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study
Lead Sponsor:
Rutgers, The State University of New Jersey
Conditions:
Healthy Participants
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a bloo...
Detailed Description
* Exposures will take place in a booth-like exposure chamber (1 x 0.7 x 1.8 m) with glass upper panels. One person will be exposed at a time. * Simulated wildfire smoke will be generated by burning pi...
Eligibility Criteria
Inclusion
- Healthy
- Non smoker
- Weight at least 110 pounds
- Between ages 18 and 40 years old
Exclusion
- Claustrophobia or not comfortable in enclosed spaces.
- Colorblindness.
- Inability to hear verbal instructions.
- Cardiovascular disease which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure. This includes a history of stroke.
- Diabetes requiring the use of insulin.
- Pregnancy (A pregnancy test will be provided to you).
- Current asthma (an asthma attack within the past five years).
- History of childhood asthma.
- Medications which may affect cognition such as beta-blockers and CNS depressants.
- Respiratory symptoms in the previous 4 weeks (cough, wheezing, shortness of breath, etc.) which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure.
- Use of sedating cold/allergy medications in the previous week.
- Use of marijuana in the previous week.
- Consumption of alcohol in the previous 24 hours.
- Kidney or liver disease.
- Thyroid disease.
- High blood pressure.
- Cancer.
- Parkinson's disease.
- Pacemaker.
- Hay fever.
Key Trial Info
Start Date :
September 18 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT07151235
Start Date
September 18 2025
End Date
November 20 2025
Last Update
December 2 2025
Active Locations (1)
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1
Rutgers-EOHSI
Piscataway, New Jersey, United States, 08854