Status:
RECRUITING
Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia
Lead Sponsor:
Syracuse University
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Aphasia Following Cerebral Infarction
Stroke Ischemic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and atten...
Eligibility Criteria
Inclusion
- 18 years or older.
- No diagnosis of neurological disorder (other than stroke).
- No diagnosis of psychiatric disorder, with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention.
- No seizure within the past 6 months.
- Not pregnant.
- Does not currently have cardiac pacemaker
- In chronic phase of recovery, defined as at least 6 months post-stroke.
- Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study.
- No metal implants in the scalp or bone in the pre-frontal area of the head.
- No unhealed skull fractures.
- Onset of aphasia related to single, left hemisphere, ischemic stroke.
- Damaged brain tissue from stroke does not overlap with left hemisphere dorsolateral prefrontal cortex.
- Mild to moderate aphasia (as measured by WAB-R \*\*or QAB).
- Self-report of post-stroke fatigue (as measured on SF-CAT)
- No significant challenges with vision or hearing (with use of corrective aids if needed; eyeglasses, hearing aids).
- Willing to allow audio-recording of study sessions.
Exclusion
- Younger than 18 years old.
- Diagnosis or history of neurological disorder other than stroke.
- Diagnosis or history of psychiatric disorder with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention.
- History of seizures within the past 6 months.
- Pregnant.
- Currently has cardiac pacemaker
- \<6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study)
- Currently undergoing speech and language therapy targeting auditory comprehension or attention.
- Metal implants in the scalp or bone in the pre-frontal area of the head.
- Currently has an unhealed skull fracture.
- Onset of aphasia related to etiology other than ischemic left hemisphere stroke.
- Damaged brain tissue significantly overlaps with left hemisphere dorsolateral prefrontal cortex.
- No aphasia or severe aphasia (as measured by WAB-R \*\*or QAB).
- Does not report experience of post-stroke fatigue (as measured on SF-CAT)
- Significant challenges with vision and/or hearing (even with use of corrective aids).
- Unwilling to allow audio-recording of study sessions.
Key Trial Info
Start Date :
August 4 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2029
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07151677
Start Date
August 4 2025
End Date
November 1 2029
Last Update
September 3 2025
Active Locations (2)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109
2
Syracuse University
Syracuse, New York, United States, 13244