Status:
ENROLLING_BY_INVITATION
Effects of Prolonged Continuous Theta Burst Stimulation in Chemotherapy-induced Peripheral Neuropathy
Lead Sponsor:
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Conditions:
Breast Cancer Females
Eligibility:
FEMALE
18-80 years
Phase:
NA
Brief Summary
Laboratory studies have shown that prolonged continuous theta burst stimulation (pcTBS) provides better pain relief than 10 Hz repetitive transcranial magnetic stimulation (rTMS), with a shorter stimu...
Detailed Description
\*\*Phase 1:\*\* Investigators will recruit 20 breast cancer patients who have chemotherapy-induced peripheral neuropathy. They will be randomly divided into two groups. * Group 1 will first receive ...
Eligibility Criteria
Inclusion
- breast cancer patients aged between 18- and 80-years-old with CIPN
- history of receiving chemotherapy including taxane-based neurotoxic agents
- with neuropathic pain, score≥3 in a 0-10 VAS pain scale.
- with fair cognition and can cooperate to evaluate pain severity.
- neither at end-stage cancer nor at the estimated survival time less than 6 months.
Exclusion
- brain tumor or history of epilepsy
- intracranial metallic devices, artificial cochleae, pacemakers, or any other metal device
- recent myocardial ischemia or unstable angina
- severe cognitive dysfunction or pregnancy
- injuries or fractures in the part of neuropathic pain
Key Trial Info
Start Date :
February 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07151963
Start Date
February 17 2025
End Date
July 31 2027
Last Update
September 11 2025
Active Locations (1)
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1
Taipei Tzu Chi Hospital
New Taipei City, Taiwan