Status:
RECRUITING
A Study of LY4064912 in Healthy Participants and With Overweight or Obesity
Lead Sponsor:
Eli Lilly and Company
Conditions:
Overweight or Obesity
Healthy
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate how well LY4064912 is tolerated and what side effects may occur in healthy participants and participants with overweight and obesity - global. The study drug w...
Eligibility Criteria
Inclusion
- Age is 21-65 years old at Singapore Sites
- Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring
- Part A: Body Mass Index (BMI) within the range greater than or equal to 21 and less than 30 kilogram per square meter (kg/m²)
- Part B: a BMI greater than or equal to 27 and less than 45 kg/m²
- Part C: a BMI greater than or equal to 21 and less than 35 kg/m²
- Parts A and C: Participants must weigh 60 kilograms (kg) or more at screening
- Have had a less than 5% change in body weight for 3 months before screening
- Safety laboratory tests are within normal reference range
Exclusion
- Have a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the investigational product; or of interfering with the interpretation of data
- Have history of diabetes (except gestational diabetes) or current diagnosis of diabetes (any form), or have HbA1c greater than or equal to 6.5% (48 millimole per mole (mmol/mol)) at screening
- Are individuals of childbearing potential (IOCBP).
Key Trial Info
Start Date :
August 28 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2026
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT07152002
Start Date
August 28 2025
End Date
October 1 2026
Last Update
December 9 2025
Active Locations (3)
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1
Collaborative Neuroscience Network - CNS
Los Alamitos, California, United States, 90720
2
ICON Early Phase Services
San Antonio, Texas, United States, 78209
3
Lilly Centre for Clinical Pharmacology
Singapore, Singapore, 138623