Status:
RECRUITING
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Postoperative Nausea
Postoperative Vomiting
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and red...
Eligibility Criteria
Inclusion
- Adult Inclusion Criteria
- Age ≥ 18 years
- Planned surgery with general anesthesia with endotracheal intubation or laryngeal mask airway
- Meet zero or more risk factors for PONV ( history of motion sickness or postoperative nausea and vomiting, non-smoker, female sex, duration of inhalation anesthesia greater than 1 hour, undergoing high risk surgical procedure (cholecystectomy, laparoscopy, gynecologic), and perioperative opioid use)
- Adult Exclusion Criteria
- ASA 6 including organ procurement,
- Patients anticipated to be transferred directly to the intensive care unit intubated,
- Procedure types:
- Electroconvulsive therapy,
- Intubation only cases,
- labor epidurals,
- transesophageal echocardiography (TEE)/cardioversion,
- surgery duration \< 30 minutes.
- Operating Room Anaesthesia Provider Inclusion Criteria
- Any operating room anaesthesia provider of eligible patients will be included.
Exclusion
Key Trial Info
Start Date :
September 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
13120 Patients enrolled
Trial Details
Trial ID
NCT07152249
Start Date
September 3 2025
End Date
September 1 2026
Last Update
November 12 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212