Status:
NOT_YET_RECRUITING
Impact of a One-Week Discontinuation of Semaglutide on Gastric Retention and Endoscopic Mucosal Visibility Scores
Lead Sponsor:
Fudan University
Conditions:
Gastric Retention
Eligibility:
All Genders
18+ years
Brief Summary
A prospective, single-center, observational study to compare the risk of gastric retention and endoscopic mucosal visibility between the exposure group (one-week discontinuation of semaglutide before ...
Detailed Description
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) mimic the action of endogenous GLP-1 hormones by activating GLP-1 receptors in the pancreas, brain, and gastrointestinal tract. This results in enh...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Subjects who have either: (i) been on long-term semaglutide therapy (≥4 weeks, any dosage) and discontinued use for one week prior to gastroscopy (with the last dose 8-14 days before the procedure), or(ii) never used semaglutide.
- For patients with diabetes mellitus (DM), HbA1c \< 9% to ensure adequate glycemic control.
- Age ≥ 18 years, with no restriction on sex.
- American Society of Anesthesiologists (ASA) physical status classification I-II.
- Fasting for at least 8 hours and no water intake for at least 4 hours before gastroscopy.
- Undergoing painless (sedated) endoscopy.
- Exclusion Criteria
- History of hiatal hernia or any previous gastric surgery (including gastrectomy, Roux-en-Y gastric bypass, etc.).
- Pregnancy.
- Medically unfit for gastrointestinal endoscopy.
- Deemed unsuitable for participation at the discretion of the investigators.
Exclusion
Key Trial Info
Start Date :
September 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 15 2028
Estimated Enrollment :
418 Patients enrolled
Trial Details
Trial ID
NCT07152756
Start Date
September 15 2025
End Date
September 15 2028
Last Update
September 3 2025
Active Locations (1)
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1
Huadong hospital, Fudan university
Shanghai, Shanghai Municipality, China, 200040