Status:
RECRUITING
Rectal Ozone as Neuroprotector Post CNS Insult in Children
Lead Sponsor:
Al-Azhar University
Conditions:
Rectal Ozone
Neuroprotector
Eligibility:
All Genders
1-18 years
Phase:
NA
Brief Summary
This study aims to evaluate the efficacy of rectal ozone therapy as a neuroprotective modality in Pediatric acquired brain injury.
Detailed Description
Acquired brain injury (ABI) from primary neurologic diagnoses accounts for 20% of all pediatric critical care admissions and more than 60,000 hospital admissions annually. Ozone (O3) gas was discover...
Eligibility Criteria
Inclusion
- Age from 1 month to 18 years.
- Both sexes.
- Children admitted to the pediatric intensive care unit (PICU) with acquired neurological insult.
- Children with neurological sequelae
- Children who are exposed to acquired brain injury, e.g., traumatic brain injury, cardiac arrest, intracranial hemorrhage, central nervous system infections, stroke, tumor, or hypoxia, with neurological sequelae diagnosed by neurological examination and magnetic resonance imaging (MRI), to detect that disorder early.
Exclusion
- Patients with no degree of disability or sequelae.
- Patients not fit for Rectal ozone therapy.
- Patients with active epilepsy and recurrent seizures.
- Children with a positive family history of degenerative brain insults.
- Children with behavioral problems.
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07153627
Start Date
May 1 2025
End Date
October 1 2025
Last Update
September 4 2025
Active Locations (1)
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1
Al-Azhar University
Cairo, Egypt, 11651