Status:
COMPLETED
Taste Alteration, Sarcopenia, and Malnutrition in Gynecologic Cancer Patients Receiving Carboplatin-Paclitaxel Chemotherapy
Lead Sponsor:
Ankara Etlik City Hospital
Conditions:
Ovarian Cancer (OvCa)
Fallopian Tube Cancers
Eligibility:
FEMALE
18+ years
Brief Summary
This observational study aims to evaluate chemotherapy-induced taste alterations, sarcopenia, and malnutrition in patients with gynecologic malignancies (ovarian, fallopian tube, and endometrial cance...
Detailed Description
Gynecologic malignancies, including ovarian, fallopian tube, and endometrial cancers, are among the leading causes of morbidity and mortality in women. Standard first-line treatment with carboplatin a...
Eligibility Criteria
Inclusion
- Histologically confirmed diagnosis of non-metastatic ovarian, fallopian tube, or endometrial cancer
- Planned to receive adjuvant or neoadjuvant carboplatin-paclitaxel regimen (carboplatin AUC 5 + paclitaxel 175-200 mg/m² every 21 days)
- No prior chemotherapy
- Age ≥ 18 years, female
- Completion of 6 cycles of carboplatin-paclitaxel treatment
- Availability of CT imaging at baseline, after third cycle, and after sixth cycle
- Ability to provide written informed consent
Exclusion
- Metastatic disease or palliative treatment setting
- Treatment with regimens other than carboplatin-paclitaxel or weekly protocols
- Prior systemic therapy (e.g., immunotherapy, targeted therapy) Initial treatment discontinuation due to progression, toxicity, or patient preference
- Missing CT imaging at required timepoints
- Pregnancy or breastfeeding
- Cognitive impairment or inability to provide informed consent
- Severe comorbid conditions (e.g., uncontrolled cardiac disease, end-stage renal failure, advanced liver failure)
- Inability to comply with study assessments or follow-up visits
Key Trial Info
Start Date :
March 15 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2025
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT07154966
Start Date
March 15 2024
End Date
July 1 2025
Last Update
September 4 2025
Active Locations (1)
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1
Ankara Etlik City Hospital
Ankara, Yenimahalle, Turkey (Türkiye), 06210