Status:
NOT_YET_RECRUITING
Effect of Simulated Weight Loss on the Energy Cost of Locomotion in Overweight or Obese Adolescents
Lead Sponsor:
Centre Hospitalier Emile Roux
Conditions:
Obesity and Overweight
Eligibility:
All Genders
12-16 years
Phase:
NA
Brief Summary
Current literature suggests that part of the energy response to weight loss is not due to changes in fat mass and lean mass, but rather to a homeostatic adaptation aimed at limiting or even preventing...
Eligibility Criteria
Inclusion
- Adolescents aged 12 to 16 (inclusive), at Tanner stage 3-5, with obesity defined as a body mass index (BMI) above the 97th percentile according to national growth charts.
- No regular consumption of tobacco or alcohol,
- No diet (no calorie restriction, no specific diet such as a normal-calorie diet enriched with protein, vegetarian, or other),
- Adolescents affiliated with the social security system or equivalent,
- Adolescent who has been informed and has given written consent to participate in the study,
- Signed consent of both holders of parental authority (or one in the event of death, major incapacity, or withdrawal of parental authority).
Exclusion
- Refusal to participate in the study,
- Refusal of consent by parents or guardians,
- Participation in regular and intense physical and sporting activities (no more than 150 minutes of moderate structured activity per week (according to WHO recommendations),
- Medical or surgical history deemed by the investigator to be incompatible with the study,
- Presence of diabetes or any other condition limiting the application of either strategy being tested,
- Adolescents undergoing energy restriction or a weight loss program through physical activity at the time of inclusion or during the previous 6 months,
- Taking medications that may interfere with the study results.
- Adolescents with cardiovascular problems, i.e., subjects with a history of cardiovascular and/or neurovascular disease, as well as subjects with cardiovascular and/or neurovascular risk factors (excluding obesity/overweight).
- Surgery in the previous 3 months,
- Adolescents who are currently excluded from another study,
- Pregnant or breastfeeding adolescents,
- Adolescents under guardianship/curatorship or legal protection,
- Parents under guardianship/curatorship or legal protection.
Key Trial Info
Start Date :
September 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07155746
Start Date
September 12 2025
End Date
May 31 2027
Last Update
September 19 2025
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